Pair Name	Ginsenoside Rb1, Cisplatin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Biological Phenomena	Inhibition-->Two efflux pumps
Gene Regulation	Down-regulation	Expression	GLI2	hsa2736
	Down-regulation	Expression	ABCB1	hsa5243
	Down-regulation	Expression	PTCH1	hsa5727
	Down-regulation	Expression	SHH	hsa6469
In Vitro Model	A549/DDP	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_C0W4
In Vivo Model	6×10⁶ A549 or A549/DDP cells were subcutaneously injected into BALB/c-nu mice to establish the model of tumor-bearing mice.
Result	Ginsenoside Rb1 for overcoming cisplatin-insensitivity of A549/DDP cells in vitro and vivo through the dual-inhibition on two efflux pumps of ABCB1 and PTCH1